Lessons learned from Blue Zones: lifestyle medicine pillars to enhance wellbeing and longevity

by | Jul 10, 2025 | Blog

Reference: Kreouzi M, Theodorakis N, Constantinou C. Lessons learned from blue zones, lifestyle medicine pillars and beyond: An update on the contributions of behavior and genetics to wellbeing and longevity. American Journal of Lifestyle Medicine. 2022;18(6):750-765. doi:10.1177/15598276221118494

 Abstracted by: David Ryland, PT, DPT, OCS, COMT, Anchorage, Alaska – Fellowship Candidate, IAOM-US Fellowship Program & Jean-Michel Brismée, PT, ScD, Fellowship Director, IAOM-US Fellowship program.

Context:
Centenarians are disproportionately concentrated in certain global regions known as “Blue Zones.” The factors contributing to this phenomenon appear less mysterious when distilled into seven identifiable lifestyle principles.

Objective:
To compare the seven Blue Zone principles with the six Pillars of Lifestyle Medicine, and to examine the interaction of behavioral, metabolic, and genetic factors in promoting longevity and well-being.

Type of Review:  Analytic Review

Details of Paper:

The seven Blue Zone principles are:

  1. Move naturally
  2. Eat wisely
  3. Avoid stress
  4. Get adequate and restorative sleep
  5. Keep strong family ties
  6. Stimulate strong community support
  7. Respect for the plant and having a purpose in life.

The six Pillars of Lifestyle Medicine are:

  1. Healthy eating
  2. Physical activity
  3. Avoidance of risky substances
  4. Stress management and maintenance of good mental health
  5. Restorative sleep
  6. Positive family and social connections.

Behavioral Insights:

  • Nutrition: Emphasizes plant-based diets, Mediterranean-style eating, caloric moderation (e.g., “Hara Hachi Bu” – stop eating when 80% full), and moderate alcohol intake.
  • Physical Activity: Encourages daily, naturally occurring movement (e.g., walking, gardening). Guidelines include 150 minutes/week of moderate aerobic activity plus twice-weekly resistance training.
  • Substance Avoidance: Includes abstaining from tobacco, vaping, and excessive alcohol.
  • Stress and Mental Health: Strongly linked to physical well-being. Chronic stress, common in developed nations, can be mitigated through sleep, exercise, social connection, laughter, mindfulness, and enjoyable activities.
  • Sleep: Adults should get 7–9 hours of quality sleep per night. Napping has been shown to reduce cardiovascular risk and depressive symptoms in older adults. Poor sleep contributes to hormonal imbalance and increased risk of chronic disease.
  • Family and Social Support: Strong interpersonal bonds are protective against mental decline, poor life quality, and early mortality.
  • Purpose and Planet: A sense of purpose enhances self-esteem and longevity. Respect for the planet, while less scientifically substantiated, may reflect broader ecological mindfulness that supports well-being.

Genetic Factors:
Research highlights three key genes associated with longevity in Blue Zone populations:

  • FOXO3A (Forkhead box O3a)
  • ApoE2 (Apolipoprotein E2) – protective against Alzheimer’s disease
  • HLA (Human Leukocyte Antigen) – related to immune function

Main Outcomes: There is considerable overlap between the Blue Zone principles and the Pillars of Lifestyle Medicine. Both emphasize modifiable lifestyle factors—nutrition, physical activity, social connection, sleep, and stress management—as critical to longevity. Genetics also play a contributory role.

Application Healthcare providers, including physical therapists, should actively educate patients on these modifiable behaviors. These lessons are low hanging fruit that can begin to be implemented the next day. Distributing simplified summaries or handouts of the seven Blue Zone lessons can encourage patients to adopt preventive strategies that combat chronic disease and promote long-term health—especially in populations like the United States, where preventable disease burden is high.

Conclusions: The Blue Zones are regions of the world with individuals living far past the average life expectancy. Longevity is multifactorial that includes environmental, behavioral, psychological, and genetic factors. There are seven pillars from the Blue Zones that closely align with the six pillars of Lifestyle Medicine with the one difference being “respect for the planet,” a concept that currently lacks robust scientific validation.

IAOM-US comments:

Teaching the lessons learned from the Blue Zones is essential for physical therapists because it allows them to promote a more holistic, preventive, and sustainable model of health. By integrating key principles in their patient management approach—such as regular natural movement, strong social connections, purposeful living, and healthy lifestyle habits—physical therapists can empower patients to make long-term changes that reduce chronic disease risk, improve physical function, and enhance overall well-being. This approach aligns closely with the physical therapy profession’s mission to optimize quality of life and movement across the lifespan, not just through rehabilitation, but through education and prevention rooted in evidence-based lifestyle practices.

Much of the supporting data is observational and preliminary. While causality remains unclear, the convergence of behavioral and genetic factors in these regions suggests a complex, synergistic model of health and longevity.